Inhibits the activity of Dickkopf 1 (DKK-1) which is a pathogenic mediator related to pattern baldness. DKK-1 is also known as the “true hair follicle killer”. Oligopeptide-41 is the major ingredient to help prevent hair loss.
Acts as an anti-inflammatory, soothing and calming agent. It also serves as an anti-histamine and immuno-suppressor to reduce itchiness and hence scratching by inhibiting the autoimmune response. It is effective in preventing psoriasis. Moreover, it functions as an inhibitor of fibroblast growth factor-5 (FGF-5), a substance that induces regression of hair follicle and regulates hair growth. Decapeptide-19 antagonizes FGF-5’s activity in living organism and acts against hair loss.
Stimulates the formation of primary hair placodes and generates new hair follicles by β-catenin and the sonic hedgehog (SHH) signal. SHH has an important role in the development and morphogenesis of hair follicles. Decapeptide-18 serves as an effective therapeutic agent in promotion of hair growth.
Stimulates hair growth by increasing angiogenesis and facilitating the migration of stem cells. Octapeptide-2 also speeds up instant progeny to the base of follicles, differentiation, and extracellular matrix remodelling.
Boosts hair pigmentation by stimulation of melanogenesis, a complex process in which the pigment melanin is produced in melanosomes by melanocytes. The final product leads to a range of brown and black pigments that gives hair its healthy color.
Fabrizio, R. L., Rita, R., Barbara, M., Daniela, P., Marco, C., Elisabetta, S., & Fabio, R. (2019). Evaluation of A Pool of Biomimetic Peptides on Human Hair Follicles: A Preclinical Study. Archives of Dermatology and Skin Care, 2(1), 11–17. https://doi.org/10.22259/2638-4914.0201003
Hirt, P. A., & Paus, R. (2019). Healthy Hair (Anatomy, Biology, Morphogenesis, Cycling, and Function). Alopecia, 1–22. https://doi.org/10.1016/b978-0-323-54825-0.00001-6
Ito, C., Saitoh, Y., Fujita, Y., Yamazaki, Y., Imamura, T., Oka, S., & Suzuki, S. (2003). Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5. Journal of Cellular Physiology, 197(2), 272–283. https://doi.org/10.1002/jcp.10369
Kwack, M. H., Kim, M. K., Kim, J. C., & Sung, Y. K. (2012). Dickkopf 1 Promotes Regression of Hair Follicles. Journal of Investigative Dermatology, 132(6), 1554–1560. https://doi.org/10.1038/jid.2012.24Yu, S.-H., Kim, Y., Jung, N., Hwang, J. W., Kim, N., Ha, J.-C., Kim, M. J., Lee, Y., Choi, Y.-S., Han, K., & Kim, C.-H. (2019). Hair growth-promoting effect of recombinant human sonic hedgehog proteins. Biomedical Dermatology, 3(1). https://doi.org/10.1186/s41702-019-0047-x